2024 - Greening Solid-Phase Peptide Synthesis: Improving Sustainability While Maintaining Crude Purity

Discover an informative webinar that presents strategies and highlights data that demonstrate the reduction of both solvents and reagents during solid-phase peptide synthesis, elimination of dimethylformamide (DMF) usage completely and how to leverage automation platforms to maintain or increase overall crude purity.
Twenty-five years ago, the twelve principles of Green Chemistry were first published, thus introducing guidelines that provide a framework to make chemistry-based research and manufacturing more environmentally friendly. With the passing of recent legislation restricting the use of common solid-phase peptide synthesis solvents (in alignment with the Green Chemistry guidelines), urgent changes to solid-phase peptide synthesis protocols are now required, not just recommended.
As a result, significant effort has been dedicated to evaluating new strategies for solid-phase peptide synthesis that are amenable to both research and manufacturing scale demands. The most critical aspect when updating established technologies is consistency.
Expectations are well established for what defines success in solid-phase peptide synthesis and new approaches must meet or exceed those expectations. Changes to the primary solvent, for example, have been demonstrated to have catastrophic effects on overall synthesis quality.
Register for this webinar today to explore innovative strategies for reducing solvent and reagent usage in solid-phase peptide synthesis while maintaining high-quality results.
Keywords: Drug Development, Peptides, Commercial Manufacturing, Peptide Synthesis, Peptide, Therapeutic Peptide Purification, Therapeutic Peptides, Solid Phase Peptide Synthesis, Basic Research