2024 - Synthesizing and Decoding Posttranslational Modifications of Disordered Proteins

Explore the structural impact of posttranslational modifications, chemical synthesis strategies, and their impact on novel drug design in this informative webinar.
Posttranslational modifications regulate the location, interactions and destruction of a protein, controlling fundamental cellular processes that are highly relevant in novel drug modality design.
However, unravelling the precise effects of these modifications on proteins is challenging because of difficulties in obtaining proteins bearing site-specific modifications for structural and functional studies. Furthermore, the impact of posttranslational modifications on protein structure is seldom investigated, leaving a gap in the knowledge of how posttranslational modifications modulate protein function.
In this webinar, assistant professor Dr. Anne Conibear from the Technical University of Vienna (TU Wien) will present her work toward understanding the structural effects of posttranslational modifications in intrinsically disordered proteins.
In the first part, she will demonstrate how solid-phase peptide synthesis provides access to modified peptides for structural studies and how protein semi-synthesis tools can generate site-specifically modified and segmentally isotope-labelled proteins for nuclear magnetic resonance (NMR) spectroscopy. Her studies reveal how integrating chemical protein synthesis with structural biology allows scientists to gain new insights into the impact of protein posttranslational modifications on protein structure, dynamics and regulation.
Luísa Aguiar, Field Application Specialist from Gyros Protein Technologies, will join the second part of the webinar, where they will take attendees on a more hands-on and practical session to some of the considerations of synthesizing peptides with posttranslational modifications, including technical strategies such as optimized amino acid deliveries on automated synthesizers, as well as ongoing challenges for an open discussion with the audience.
Don’t miss this chance to learn about the latest research in posttranslational protein modifications and a unique opportunity to obtain technical insights to synthesize these challenging peptides.
Join this exciting webinar about leveraging the chemical synthesis of posttranslationally modified peptides to study proteins using state-of-the-art peptide technology.
Keywords: Proteomics, Protein Synthesis, Peptide Synthesis, Protein Engineering, Protein, Post-Translational Modification, Basic Research