2022 - Biological Macromolecules: Exploring Analytical Development and QC Case Studies in Antibody Developability and Biologics CMC

Biological macromolecules (monoclonal antibodies, recombinant proteins, fusion proteins, antibody-drug-conjugates, polypeptides and vaccines, etc.) are powerful therapeutics, and their characterization has drawn considerable attention and urgency in the biopharmaceutical industry. A developability assessment at an early stage can provide a better understanding of candidates, deliver better and safer therapeutic candidates and reduce risk during late-stage development.
In this webinar, the featured speakers will review:
Antibody quality attributes that are critical to development and traditional and state-of-the-art analytical methods to monitor those attributes
A practical workflow for developability assessment, including in silico evaluation, extended characterization and preliminary stability studies using appropriate analytical methods
Case studies on conducting developability assessment experiments
NODATA
The speakers will discuss relevant analytical methods, including techniques (SPR, BLI, DSC, DLS, CD, LC-MS/MS, etc.) to determine thermal stability, activity, protein sequence, post-translational modifications, degradation, glycosylation, folding, disulfide bond shuffling and aggregation. An aberrant result for these attributes may raise quality issues.
Register for this webinar to get technical insight into analytical technologies in biophysical and mass spectrometry characterization as well as affinity analysis for biological macromolecules.