2019 - Live Webinar on Issues in Calibrations and Accuracy in Method Validation

OVERVIEW
One of the most important concepts and criteria of Good Laboratory Practices is accuracy, how well does a methodology stand in terms of quantifying when compared to an expected value? There are various approaches in calibration and in the use of standards for comparisons. This webinar will cover validation of calibrations and the strengths, weaknesses, and appropriateness of the different types of standards. Without accuracy, a result is not acceptable. There are many issues that have an effect on accuracy and there are many approaches to deal with them. The importance of response, matrix effects, selectivity of identification, and other issues will be covered.
WHY SHOULD YOU ATTEND
Accuracy is one of the most fundamental assessments in regulated analyses and calibration is the means to determine it. The quality, and therefore the acceptability, of accuracy is a large part of an auditor’s review of a methodology. This means that the connection of how amounts are determined to known, accepted, and comparable values is a key. This is often difficult when dealing with new compounds assessed by new methods. Approaches to increase the quality of measurement will be covered.
AREAS COVERED
• How accuracy is determined in analytical method development and validation
• What are the various types of standards and what are their strengths and weaknesses
• Analytical method validation and the importance of traceability
• Calibration curves – what are the important criteria?
• Linearity versus nonlinearity, slope, intercept and what they mean
• Matrix effects and how to deal with them
• Using calibration data to monitor performance
LEARNING OBJECTIVES
• Comparison by using standards – the types of standards
• Traceability and documentation in analytical method development and validation
• Calibration curves – checks for linearity, when non-linearity happens
• Spikes, surrogates, and standard addition
• Monitoring calibrations – slope and intercept
WHO WILL BENEFIT
• Lab Chemists
• Lab Managers
• Lab Technicians
• Lab Analysts
• Industries into Compliance Methodology (Biotech, Pharma)
• Companies into Environmental Compliance (EPA)
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