Melanoma 2011 - 5th Canadian Melanoma Conference

2011 Canadian Melanoma Conference
February 24 to 27, 2011
Fairmont Banff Springs Hotel, Banff, Alberta

?色素瘤是起源于神?外胚叶、?生于?色素?胞或其母?胞的?性?瘤，在世界范?内?病率逐年升高。皮??色素瘤的?性程度高，生?迅速，?后大多很差，因此早期?断和及?正确治?十分重要。治?上??早期??和局部?大切除。但皮??色素瘤?床表???，容易??，尤其是无色素型?色素瘤。若未能早期?断，病?呈侵?性?展，早期可?生?移，?移部位多?肺、?。?期可能并?淋巴?等部位的?隔?移。病?位于肢端者，常需行截指（趾）或截肢?。2010年12月22日上映的《非?勿?2》将“痣”和“?色素瘤”拉到了一起，??雷扮演的李香山脚面上的一??痣，最后?成?他致命的不治之症――“?色素瘤”。

The Canadian Melanoma Conference is Canada's flagship meeting on the research and treatment of melanoma. It brings together Medical Oncologists, Surgeons, Dermatologists, Radiotherapists, Pathologists, Molecular Biologists, and Immunologists to review the latest evidence and explore new therapies.

New this year - Case study presentations and "short snappers"
Share new and current research at this years' conference. Submit your ideas on new research initiatives in the diagnosis and treatment of melanoma. Your ideas will be reviewed by the organizing committee for consideration in these sessions. See the 'abstracts' section of the website for further details.

Themes:
Basic Science and Pathology
Dermatology and Surgery
Systemic Therapy / Immunology
Keynote speakers include:
Boris Bastian, Memorial Sloan-Kettering Cancer Center, New York
Vernon Sondak, I. Lee Moffitt Cancer Center & Research Institute, Tampa
Léon van Kempen, Department of Pathology, McGill University
Dirk Schadendorf, Professor, Department of Dermatology, Universitätsklinikum Essen
Who should attend?
Medical Oncologists, Surgeons, Dermatologists, Radiotherapists, Pathologists, Molecular Biologists, Immunologists

2011 Organizing Committee
Michael Smylie (Chair)
Cross Cancer Institute; Division of Medical Oncology, University of Alberta, Edmonton

Joel Claveau
Melanoma and Pigmented Lesions Clinic, CHUQ, Hôpital Hôtel-Dieu de Québec, Quebec

Scott Ernst
Division of Medical Oncology, London Regional Cancer Program, London

J. Gregory McKinnon
University of Calgary and Tom Baker Cancer Centre, Calgary

Teresa Petrella
Sunnybrook Odette Cancer Centre, Toronto

Thomas G. Salopek
Department of Dermatology, University of Alberta, Edmonton

Alan Spatz
Department of Pathology, Jewish General Hospital, Montreal
David Hogg
Departments of Medicine and Medical Biophysics, University of Toronto, Toronto

Jewel Buksa
BUKSA Strategic Conference Services, Edmonton

http://www.buksa.com/melanoma/

Melanoma (pronounced /?m?l??no?m?/ ( listen)) is a malignant tumor of melanocytes. Such cells are found predominantly in skin, but are also found in the bowel and the eye (see uveal melanoma). Melanoma is one of the less common types of skin cancer, but causes the majority (75%) of skin cancer related deaths.[1] Melanocytes are normally present in skin, being responsible for the production of the dark pigment melanin.[2] Despite many years of intensive laboratory and clinical research, early surgical resection of thin tumors still gives the greatest chance of cure.
Around 160,000 new cases of malignant melanoma are diagnosed in the world each year. It is diagnosed more frequently in women than in men and is particularly common among Caucasians living in sunny climates, with high rates of incidence in Australia, New Zealand, North America, and northern Europe.[3] According to a WHO report about 48,000 melanoma related deaths occur worldwide per year.[4]
The treatment includes surgical removal of the tumor, adjuvant treatment, chemo- and immunotherapy, or radiation therapy.

?色素瘤(?名：?色素?胞瘤，色素病，脱疽，?疽)　，是由异常?素?胞?度?生引?的常?的皮??瘤，?性程度极高，占皮??瘤死亡病例的极大部分。多?生于皮?或接近皮?的黏膜，也?于??膜和脉?膜。其?病率随人?、地域、?族的不同而存有所差异，白?人的?病率????人高，居住在澳大利?昆士?州的白?人其?病率高达17/10万。我国?属?色素瘤的低?区，但近年来?病率却呈不断上升??。[1]
?年美国有25000个?性?素瘤新?病例，死亡?6000人。?病率在急速上升。日光照射是危?因素，同?危?因素?包括家族史，?生?性斑痣，?大的先天性?素?胞痣和?育不良性痣?合征。?人少?。
多数?性?素瘤均起源于正常皮?的?素?胞，?40%~50%?生于色素痣(参?第125?痣和?育不良性痣)。?性?素瘤在儿童中很少?，但可源于出生即有的非常巨大的色素痣。?痣通常会自行消失但在极少数病例会成??素瘤。?然?孕期易罹患?素瘤，但妊娠并不?加色素痣????素瘤的可能性。在?孕期?，痣的形状和大小常有?化。以下危?信号提示色素痣??：大小改?，?色改?，??，?白，??，特?是色素沉着区向周?正常皮??散；表面特征改?，?地形状的改?；尤其是痣周?皮?出?炎症反?，可能有出血，??，瘙痒或疼痛等表?。
?性?素瘤在大小，形状和?色(通常色素沉着)及局部侵?和???移的?向方面均有不同。??瘤?散迅速，可在?断数月后死亡。早期，非常表浅的病?5年治愈率可?100%。所以治愈率取决于早期?断，早期治?。
?色素瘤 - 病因
?色素瘤是由什?原因引起的？
?病原因
?色素?胞瘤可由表皮?色素?胞，痣?胞或真皮成?色素?胞?成。?瘤起源于外胚叶的神??，?色素?胞位于表皮?与基底?胞?排列，?胞?生色素后，通??状突将?色素?粒?送到基底?胞和毛?内。大多数?性?色素瘤的?生，是由于?色素痣受到反?的摩擦、抓起和??而引起??，不适当的挖除和?物腐?等，可使良性?色素痣?化成?性?色素瘤。孕期或生育年?的?女会使?性?色素瘤?展迅速，提示本病与内分泌有?。从年?上看，多?生在中老年人，很少数?生在青春期前。据?道：84%?性?色素瘤来自良性痣。据Wieeio?告，由于痣太小的?故，?多病人患病初期都没有注意到。有人??良性痣是?性?色素瘤的最大根源。

中医??：?性?色素瘤?生由于?邪搏于血气，?化所生;或脉?之血，滞于?分，阳气束?而成;?中?气混于阳，阳气收束所致，和血凝气滞等因素有?。

正常?色素?胞瘤?的真正原因尚不清楚，与下列因素可能有?：

(1)大气?染　氟里昂等有害物?的大量排放破坏了臭氧?，造成紫外???不充分，有害的紫外?与空气中的有害物?携手共同作用于人体皮?，造成?素?胞异常表达，引??素瘤。

(2)?美之心作怪　?多人?了追求皮?的?嫩而大量使用化学?化?品，造成化学性皮??染，甚至有人用化学腐??去除掉皮?上的?痣，?果适得其反，刺激了?素?胞的?度?殖。

(3)?生知?缺乏　??在足部、会?部等易受摩擦部位的?痣未引起足?重?，凭其?期受到??与摩擦，?致其?生?性??。

(4)?用雌激素??物　研究???性?色素瘤的?胞内有雌激素受体，因此，人??疑雌激素?量会刺激?色素瘤的?生。

(5)免陷缺陷　随着生活水平的提高，中国人寿命明?延?。伴随年?的??，人体免疫功能逐?衰退。研究??，免疫功能低下是?色素瘤?生的重要原因之一，所以?床上老年人?色素瘤的?病率很高。

(6).良性?色素斑? 即?痣，其中交界痣最易??，混合痣?少，而内皮痣?极少??。但?皮?色素瘤多数并非?痣??而来，故有人??本病不完全与?痣有?。

(7).?族 白人比有色人??病率高，如美国白?人的年?病率高达42/10万，而?人??0.8/10万。
?病机制
病?多?生于真皮和表皮交界?，瘤?胞?似痣?胞，但明?异型，?胞??和?胞内充??色素，根据?胞形?和?色素量的不一，可分5型：

1.大上皮??胞 多?，?胞呈多?形。

2.小上皮??胞 核大而不典型。

3.梭形?胞 胞?呈原???，核大染色深。

4.畸形?胞 ??核或多核。

5.?枝突?胞 比正常?色素?胞大，胞核异型，瘤?胞?酪?呈?阳性反?，含?色素少?，在HE切片内?以??，故有“无?色素性?色素瘤”之称，但若用?染色，在少数?胞内仍可?出?色素。