2018 - Immunoprecipitation of Disease-Associated Proteins for Alzheimer’s Research

Alzheimer’s disease is the most common neuropsychiatric disorder in the aging population and is characterized by extracellular deposits of aggregated amyloid-β (Aβ) peptides, intracellular tangles, and loss of synapses. The last several decades have seen an explosion in studies of the role of Aβ in the progression of Alzheimer’s disease which has been translated into promising novel therapies with putative disease-modifying effects. Up until recently, no biomarkers reflecting the third hallmark, progressive dysfunction and degeneration of synapses, have been available.