2017 - Neuroprotective Treatment Strategies in Multiple Sclerosis

The TRPM4 ion channel is a member of the Transient Receptor Potential Melastatin family, and is permeable to monovalent cations but impermeable to calcium. Deletion of this gene in mice ameliorates the course of disease progression in an animal model of multiple sclerosis (MS). TRPM4 deletion does not influence the disease-relevant immune response in knockout mice in the animal model of MS.