2013 - ANTI-HYPERLIPIDEMIC ACTIVITY OF CUCUMIS MELO FRUIT PEEL DIFFERENT EXTRACT IN TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS

ANTI-HYPERLIPIDEMIC ACTIVITY OF CUCUMIS MELO FRUIT PEEL DIFFERENT EXTRACT IN TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS
Jayant S. Bidkar *, Madhuri D. Bhujbal , Ganesh Y. Dama
Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Dumberwadi (Otur), Tal.Junner, Dist.Pune, 410504, Maharashtra, India.
ABSTRACT:
Cucumis melo Linn. (Cucurbitaceae) fruits have been used, traditionally, for the treatment of various disorders of heart as Cardioprotective and antiobesity. The aim of the present study was to investigate the possible anti-hyperlipidemic activity of Cucumis melo fruit peel extract in triton induced hyperlipidemia in rats. Chloroform, Methanolic and aqueous extracts of were administered to the triton induced hyperlipidemic rats for 7 days to study antihyperlipidemic acivity. The acute toxicity value of chloroform, methanol and aqueous extract after oral administration in mice were found to be 5000 mg/kg. The results concluded that CMFP methanolic extract (500 mg/kg) have definite antihyperlipidemic activity in Triton X-100 induced hyperlipidemia model and which is equipotent activity when compared with Atorvastatin treated group.