2024 - Bioprocessing Economics: High Titre for Show, Net Titre for Profitable Growth

In advanced bioprocessing, achieving high titres in microbial production is celebrated. However, the ultimate measure of success lies in the net titre, which considers both efficiency and yield as the protein moves through and out of downstream processing (DSP).
Traditional bioprocessing methods prioritize optimizing expression systems for high titres using standard host cells like Chinese hamster ovary (CHO) or Pichia pastoris. While effective initially, these methods frequently fall short in net yield due to inefficiencies in DSP. Complex purification processes, increased costs and reduced efficiency often result from high initial titres.
Balancing impressive initial titres with the practical economic realities of purification and overall yield is a critical challenge faced by drug developers with clinical manufacturing aspirations. These limitations underscore the necessity for a comprehensive bioprocess optimization strategy integrating both upstream and downstream processes.
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Register for this webinar today to understand how to maximize net titres in bioprocessing through an integrated approach that combines high titre production with efficient downstream processing.
Keywords: Biologics, Biosimilars, Process Development, Biomanufacturing, Commercial Manufacturing, Biologics Manufacturing, Downstream Processing, CDMO/CMO, Strain Development, Bioprocessing