2024 - Addressing the Issue of Genomic Stability in iPSCs: New Approach for Restoring Cell Lines

Induced pluripotent stem cells (iPSCs) have revolutionized cell-based therapeutics, drug discovery and many other scientific fields. However, despite significant advancements in iPSC culture, several challenges remain regarding the reliability, reproducibility and consistency of cell cultures, assays and data. These challenges not only lead to significant costs and time on projects but also affect the quality of the final product.
This webinar focuses on the different types of quality control (QC) required for iPSCs, with an emphasis on the International Society for Stem Cell Research (ISSCR) standards guidance. Genomic stability assessment is a crucial part of QC since up to 30 percent of cultures have genomic or genetic changes that can affect downstream usage with significant implications for cell-based therapeutics.
To address these challenges, the expert speakers will focus on a novel solution that recovers iPSC lines with mosaic genomic or genetic abnormalities. Cellected Ltd.’s novel solution, RESCUE, combines high-throughput single-cell cloning with the Advanced Instruments VIPS® PRO and rapid genomic screening to recover normal cells from the population. The Cell Metric® X platform enhances clone selection and growth analytics and, combined with bespoke functional QC, enables the rapid return of the normal cell line to customers.
Register for this webinar to learn about the latest advancements in iPSC culture and quality control and take the first step towards improving the reproducibility, reliability and consistency of cell cultures, assays and data.
Keywords: Quality Control, Drug Development, Drug Discovery, Cell Therapy, Genomics, High Throughput Screening, Quality Assurance, Laboratory Technology, iPSCs, Cell Line Development, Cell & Gene Therapies, Quality, Basic Research, Stem Cell