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Check with your doctor immediately if any of the following side effects occur while taking fluorouracil topical: Incidence not known Black, tarry stools bleeding gums blood in the urine or stools chest pain chills cough fever painful or difficult urination sore throat sores, ulcers, or white spots in the mouth or on the lips swollen glandsSide Effects Specific side effects that usually do not require medical attention include: 1 Red or dark-colored skin Erosion (loss of the upper layer of skin) Eye irritation, including burning, itching, sensitivity, stinging, or watering Photosensitivity (skin sensitivity to ultraviolet light) Pain and burning of the affected areapainful or difficult urination. sore throat. sores, ulcers, or white spots in the mouth or on the lips. swollen glands. trouble breathing. unusual bleeding or bruising. unusual tiredness or weakness.Common side effects of Efudex may include: skin pain, itching, burning, or irritation; skin darkening or scarring; skin redness and swelling; or. small blood vessels under the skin. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects . You may report side effects to FDA at 1-800-FDA-1088.Common side effects of Efudex include: skin irritation, burning, redness, dryness, pain, swelling, tenderness, scaling, peeling (exfoliation), rash, changes in skin color at the site of application, or other local reactions. Other side effects of Efudex include eye irritation (e.g., stinging, watering), trouble sleeping, irritability,The most frequent adverse reactions to Efudex occur locally and are often related to an extension of the pharmacological activity of the drug. These include burning, crusting, allergic contact dermatitis, pruritus, scarring, rash, soreness, and ulceration.Common side effects of Efudex include. stinging, burning sensation, irritation, sun sensitivity, pain, itching, swelling, allergic reactions, and; redness. Serious side effects of Efudex include. ulcer formation, loss of pigmentation (hypopigmentation), scarring, and; bacterial infection. There are no known drug interactions with topical Efudex .
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