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Overall tibolone was well tolerated and climacteric symptoms were relieved within 3-5 weeks. The major side effect was weight gain and/or a tendency to bloating and oedema which occurred in 11.28% of our women. How do you take tibolone Amena? The usual dose is 2.5 mg daily by mouth.Side effects may include stomach, breast or pelvic pain, increased hair growth, vaginal spotting or irregular bleeding, acne, weight gain , swelling of hands and feet, vaginal irritation or thrush and itchy skin.
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