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Zofran ODT (ondansetron) is an antiemetic drug that helps prevent nausea and vomiting. This prescription medication dissolves on the top of your tongue and works by preventing a chemical called serotonin from reaching certain cells in the brain. Zofran ODT is available as an orally disintegrating tablet.This medicine is also used to prevent and treat nausea and vomiting that may happen after surgery. This medicine is available only with your doctor's prescription . Before using Zofran In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.Zofran ODT orally disintegrating tablets are white, round, and plano-convex tablets available in the following strengths: 4 mg - debossed with "Z4" on one side. 8 mg - debossed with "Z8" on one side. Zofran oral solution, 4 mg/5 mL, is a clear, colorless to light yellow liquid with a characteristic strawberry odor available in a 50-mL bottle.Zofran is a brand (trade) name for ondansetron which may be used to treat or prevent nausea and vomiting. Experts aren't sure exactly how Zofran (ondansetron) works and if its antiemetic action is mediated by a direct effect on the CTZ (the area of the brain associated with vomiting), the vagus nerve, or both.Take Zofran exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Zofran can be taken with or without food. The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment.
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