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Weekly therapy may be instituted with the RHEUMATREX ® Methotrexate Tablets, USP, 2.5 mg Dose Packs which are designed to provide doses over a range of 5 mg to 20 mg administered as a single weekly dose. The dose packs are not recommended for administration of methotrexate in weekly doses greater than 20 mg.Rheumatrex (methotrexate) is an antimetabolite drug that is used to treat some cancers, severe skin diseases such as severe psoriasis, and to treat forms of rheumatoid arthritis. Rheumatrex is available in generic form. What are side effects of Rheumatrex ? Side effects of Rheumatrex include:Rheumatrex Description. Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Chemically methotrexate is N - [4- [ [ (2,4-diamino-6-pteridinyl)methyl]methyl­amino]benzoyl]-L-glutamic acid. The structural formula is:Seizures (convulsions) Shortness of breath, cough, hoarseness or wheezing. Side or lower back pain. Sloughing of skin, muscle, and bone. Unusual bleeding or bruising. Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your healthcare provider.Dosage for Rheumatrex . The dose of Rheumatrex is designed for each patient's problem and can range from about 7.5 mg per week to 30 mg per day, depending on the disease process and the doctor's judgment. Rheumatrex has been used in children with juvenile rheumatoid arthritis, and doses were individualized.How Rheumatrex (methotrexate tablets) is taken may change based on blood work results, side effects, and how well the drug is working. You will need to take special care when handling Rheumatrex (methotrexate tablets). Check with the doctor or pharmacist to see how to handle Rheumatrex (methotrexate tablets).pinpoint red spots on the skin. sores in the mouth or lips. stomach pain. swelling of the eyelids, face, lips, hands, feet, or lower legs. swelling or inflammation of the mouth. trouble breathing. unusual bleeding or bruising. vomiting. yellow eyes or skin.
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