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Prescription medicines commonly used to treat nail fungus (onychomycosis) include oral and topical treatments, such as: topical efinaconazole (Jublia) topical tavaborole (Kerydin) topical ciclopirox (Ciclodan, Penlac Nail Laquer) oral terbinafine (Lamisil) oral itraconazole (Sporanox)The top treatments for toenail fungus are: Terbinafine (Lamisil) Itraconazole (Sporanox, Sporaz, Orungal) Terbinafine for toenail fungus treatment The best pill for toenail fungus is terbinafine. Evidence suggests it works better than the alternatives with the fewest side effects. Terbinafine results in resolution of toenail fungus 76% of the time.Zinc undecylenate and undecylenic acid are both FDA-approved ingredients to treat toenail fungus . 2 Also, if you seek help from a dermatologist, they will likely prescribe medications in the "azole" family. "The compound interferes with the synthesis of the fungal cell membrane," Dr. Lipner says, which essentially kills the fungus .Amorolfine and ciclopirox are the most common topical nail fungus treatments. 6 You apply them like nail polish daily for up to a year. However, since topical medications are less effective, especially in more moderate and severe cases, healthcare providers sometimes combine them with another treatment method, like oral medication.
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