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Efudex may cause serious side effects. Stop using Efudex and call your doctor at once if you have: severe pain or swelling of treated skin; severe itching, burning, or irritation; new or worsening skin sores; fever, chills; or. severe stomach pain, bloody diarrhea, vomiting. Before your skin begins to heal it will become red, dry, tender, and ...Efudex is a topical chemotherapy treatment for basal cell carcinoma. It works by stopping cells from developing and is effective, especially when combined with surgical lesion removal. Common side effects include skin rash and irritation. Less frequently, more severe side effects can occur.Efudex was easy to use, not painful, just a gnarly scab that took weeks to fall off. Once gone, the skin was smooth but red. Red spot was 3X larger than the AK being treated (now the size of a pencil eraser). Hoping the redness will heal in time. Finished treatment two months ago but the smooth red splotch remains.
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