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Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It is available as an oral tablet, a topical gel or patch, vaginal cream , or as an injection. Estradiol is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.Estradiol Vaginal Cream , USP, 0.01% is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. Contraindications Estradiol Vaginal Cream , USP, 0.01% should not be used in women with any of the following conditions: Undiagnosed abnormal genital bleeding.Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Pelvic pain or pressure. Vaginal irritation. Vaginal itching or discharge. Vaginal bleeding that is not normal. A lump in the breast, breast pain or soreness, or nipple discharge.Applies to estradiol topical: transdermal film extended release, vaginal cream , vaginal insert, vaginal ring, vaginal tablet General The most commonly reported side effects were headache, upper respiratory tract infection, moniliasis, genital pruritus, vulvovaginal mycotic infection, and diarrhea. [ Ref] Cardiovascular
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