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Clobetasol propionate is a highly potent topical corticosteroid that has been shown to suppress the HPA axis at doses as low as 2 g per day. Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment.Clobetasol propionate has the molecular formula C 25 H 32 CIFO 5 and a molecular weight of 467. It is a white to cream-colored crystalline powder insoluble in water. Clobetasol propionate topical solution contains clobetasol propionate 0.5 mg/g in a base of carbomer 974P, isopropyl alcohol (40% w/w), purified water, and sodium hydroxide.Clobetasol topical (for the skin) is used to treat inflammation and itching caused by plaque psoriasis and skin conditions that respond to corticosteroid medication. It is available in a cream, gel, ointment, lotion , solution, foam or spray. Warnings Do not use clobetasol topical to treat acne, rosacea, or a rash around the mouth.Apply a thin layer of clobetasol propionate cream to the affected skin areas twice daily and rub in gently and completely. Clobetasol propionate cream is a super-high potency topical corticosteroid; therefore, treatment should be limited to 2 consecutive weeks, and amounts greater than 50 g per week should not be used.Clobetasol is a prescription drug. It comes as a topical cream, lotion , spray, solution, foam, ointment, and gel. It also comes as a shampoo. Clobetasol topical cream comes in two forms: regular...Clobetasol propionate lotion , 0.05% is a super-high potent topical corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses only in patients 18 years of age or older. Treatment should be limited to 2 consecutive weeks.Clobetasol Propionate Ointment USP contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol , an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.
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