Healthcare Training 2021 - 6-Hour Virtual Seminar on Adaptive Design for Clinical Trials

Clinical trials are expensive, time-consuming, and labor-intensive. And in the traditional sense, study designs are inflexible.
Adaptive study designs allow for flexibility during a clinical trial. Options can be built into a study to use data collected that has accumulated at interim time points to:
Adjust sample sizes in treatment arms or reduce patient recruitment
Drop treatment arms entirely (treatment pruning)
Adjust randomization schema
Combine Phase II and Phase III (adaptive seamless design)
Early stopping of a study for futility or success
The U.S. Food and Drug Administration (FDA) and other regulatory agencies require the minimization of bias in study design and analysis. In order to minimize bias, particular steps and safeguards, using regulatory guidance and sound statistical principles, must be put into place to assure validity of an clinical.