2019 - Lyophilization Process Development and Cycle Design with a Case Study

Thermal characterization including DSC and FDM.
Understanding the effects of working with crystalline vs. amorphous components.
The problem with working with a metastable glassy system and the use of annealing to correct this problem.
Determining optimal shelf temperatures for the freezing step.
Determining optimal shelf temperatures and chamber pressures for the primary drying step.
Determining optimal shelf temperatures and chamber pressures for the secondary drying step.
Characterization of the finished lyophilized product.