2020 - Hit-to-Lead Optimization Strategy in Drug Discovery

In vitro biochemical assays make possible the high throughput screening (HTS) of large compound libraries. A successful HTS campaign is typically viewed as one that identifies large numbers of diverse chemical series hits as potential starting points on the way to a clinical candidate. These hits are typically weakly active in a primary screen and do not necessarily possess drug like characteristics. Hit-to-Lead optimization is now a key process in drug discovery that explores the chemistry and biology of hits to focus efforts on the most promising starting points so that development time and costs are saved.
What makes a promising starting point for a drug discovery program? In this webinar, strategies to triage hits and focus efforts will be discussed.