This workshop will discuss and map-out the challenges posed by differences between the clinic and the home setting, for the design of digital technology for self-care. We aim to bring together researchers and professionals from HCI and design, and care- organizations to share their insights and experiences of being involved in various cases. We take these shared insights as the basis for exploring how the differences of various settings may influence the design of digital technology for self-care. We will collect these different perspectives in the form of selected position papers, posters, and summary of plenary discussions, and share it as an online repository for HCI researchers, professionals and students.